The NIH Guidelines (NIH Guidelines for Research Involving Recombinant DNA Molecules) require the use of an Institutional Biosafety Committee (IBC) to oversee any activities that involve biohazardous materials, especially research activities that involve recombinant or synthetic nucleic acid molecules. When conducting research that uses recombinant DNA, investigators are responsible for obtaining IBC approval.
Possible Activities that Require IBC Approval
- Infectious agents
- Human or non-human-primate materials (body fluids, cell lines, tissues)
All applicable research activities must be reviewed by the IBC, regardless of the source of funding for the proposed project.
- Greenville Health System (GHS) is registered with the NIH’s Institutional Biosafety Committee Registration Management System (IBC-RMS).
- GHS contracts with Western Institutional Review Board (WIRB) to provide IBC services.
- In accordance with NIH protocol, GHS has the appropriate personnel in place.
GHS and NIH Protocol and Personnel Responsibilities
- Reporting to the IBC and the institution any significant problems
- Violations of the NIH Guidelines
- Any significant research-related accidents or illnesses
- Developing emergency plans for handling accidental spills
- Personnel contamination
- Laboratory accidents
- Providing technical advice to Principal Investigators (PI) and the IBC on research safety procedures
These or related questions or concerns regarding IBC services at GHS may be directed to:
Jan Kueber Manager CRU GHS
Questions regarding infection control may be directed to:
Dr. J. William Kelly